It tends to hit a lot of proteins, so you can find all sorts of activities if you look for them. That said, the data will tell the story. A challenge to the explanation of quercetin bioactivity was represented, until recently, by the contradiction between its extremely low plasma concentration after oral administration and the demonstrable systemic effects.
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Apparently this doctor with a lot of street cred at one point the 6th most cited scientist in the world in Montreal is starting clinical trials of Quercetin. Already raised 1m. Past work from the SARS epidemic. The cytotoxicity of quercetin was very low, with a CC50 of 3.
Hydroxychloroquine | DermNet NZ
That is why it works in cells in vitro. From what I have read it is not very effective against viruses in vivo. My pleasure, Apthorp old chap. Pity old Ritchie-Hook blew himself up last time round on that last spot of biffing. Would have had a whale of a time this show rounding up errant civilians. Good to see that Capt Corante fellow doing a wizard job, a true Officer and Gentleman.
No higher praise to a yankee from a mere limey than that. Curcumin will raise serum zinc levels — zinc plus curcumin plus quercetin may mimic the action cholorquine in fighting COVID Whether it works in people is another question. The one thing I can think of about those in vitro studies is that the lack of Zn in cells without the chloroquine is very simplistic since lots of things could theoretically chelate zinc and help facilitate transport into the cell, even without chloroquine.
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And there is some evidence that quercetin and probably other polyphenols like tumeric can act as dietary ionophores for zinc:. Even short courses of chloroquine present a real risk hemolytic anemia to people with glucosephosphate dehydrogenase deficiency. This condition is not rare especially in people of West African ancestry.
This zinc-containing phosphatase- might it also contain iron, and if you ask nicely manganese?
Industry ups chloroquine production, donates millions of doses
If so, I had a similar experience, but never made it to elemental analysis since the molecule had other problems. Hell of a protein… built a lot of character. The coronavirus is yet another example that no one in the biological or chemical sciences has a clue what they are doing…..
Hopefully this will wake everyone up to the fact that everyone in their field can spend their whole career as a top scientist and literally be cranking out useless academic junk. Fair point. Although to be fair the virus has only functionally existed for a few short months we assume. As a chemist done time on the receiving end of cell biology, seems to me that even if biochemistry an order of magnitude or two less fuzzy, still be no mean feat to come up with a therapy in shining armour that could rescue us fast enough.
Always great fun pricking over inflated balloons. Thanks for that. Fired off to printer and set upon with with highlighter pen. Hard going for old buffer unsteeped in antivirals. Thrust is that a the? As stated on p , para Plenty to ponder. Thank you highlighter with the green and yellow pens. As concluded on p The possibility of the reemergence of SARS and other novel viruses from animals or laboratories and therefore the need for preparedness should not be ignored.
Scientific findings do not automatically trickle upwards to the powers that be. What efforts were made to make these findings known to authorities?
Chloroquine played important part in the MedChem history. It was also at the beginning of the discovery of quinolone class of antibacterials. During antibacterial screening at Sterling, they screened also some impurities from their chloroquine production and found one of them, 7-chloroethyloxo-1,4-dihydroquinolinecarboxylic acid, active against G - strains. Modification of the structure led to nalidixic acid, the first drug of the class.
It has been shown that alteration of N-linked glycans of ACE2 does impair the CoV envelope spike glycoprotein-triggered membrane fusion. If chloroquine would be effective by disturbing the biosynthesis of N-glycans e. Indeed numerous derivatives of 1-deoxynojirimycin and castanospermine iminosugars from e. N-butyldeoxynojirimycin Miglustat is an existing drug that reduces the above mentioned fusion in models, but other derivatives are more potent. Antimicrob Agents Chemother , — But it does have such effects in a percentage of the population.
My thinking is that if tens of millions of people try to take it prophylactically, we could see some trouble. Is enough known to write a story on how chloroquine metabolizes differently for people with cytochrome polymorphisms? Nice paper. The EC50s against highly pathogenic CoVs similar. Time of addition favors CQ use as primary prevention only see Vincent et al, Virology Journal , As of today, infected frontline healthcare professionals in Italy are infected. Daily administration mg hydroxyCQ should block infectivity. At least the theory is nice. For those of us who took a lot of chloroquin in the old days to ward off malaria—I spent two years in the African bush in the mids—the thought that it might make a comeback brings mixed emotions.
Chloroquine or Plaquenil: What is it and can it really treat coronavirus?
I caught malaria anyway, and the impact of the drug on everything from eyesight to liver function was hotly debated. Presumably, the medical and pharmaceutical professions have a lot better understanding of side effects of the drug today. There are mitochondrial benefits and it delays aging. Also it works with light so if you take it and go out in the sunlight it can work even better. Do you for sure know that it cant do the same thing as the pharmaceutical malaria drug. From what I understand that hydroquinine performs two functions. Increase non permeability of the cell wall making it a it more acidic and the virus proteins have less ability to cleave and also deactivation of the receptor sites as well.
Do we know that MB does not do the same thing. I am not advocating it I just used it for bio hacking the mitochondria and knew it was better at treating malaria then the hydroquinine at least that is what a study suggested. From what I understand that hydroxychloroquine performs two functions. I am not advocating it I just used it for bio hacking the mitochondria and knew it was better at treating malaria then the hydroxychloroquine at least that is what a study suggested.
Pretty widely used drug, and as several have noted, relatively benign. For short-term antiviral treatment, perhaps the possibility of QT prolongation is most concerning.
Could it work?
We need to stop being trapped by the paradox of expertise and waiting for the gold standard proofs of controlled trials. Crisis calls for breaking rules and innovating. Treatments already approved for other conditions should be applied widely now, and proofs can wait til later.
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I have great respect for our medical professionals, but this is not a time for the typical level of caution that they have all grown up in. This is a classic example of the a paradox of expertise. The existing rules regarding the use of these drugs evolved because people have been injured by them.