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High concentrations are taken up into white blood cells. There is little diffusion into the CSF when the meninges are not inflamed. Data from animal studies indicate that azithromycin crosses the placenta.
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Small amounts of azithromycin are demethylated in the liver, and it is excreted in bile mainly as unchanged drug and a number of inactive metabolites have also been detected. The terminal elimination half-life is about 68 hours. Azithromycin is a nitrogen-containing macrolide azalide with actions and uses similar to those of erythromycin. It is given in the treatment of respiratory-tract infections including otitis media , in skin and soft-tissue infections, and in uncomplicated genital infections.
Azithromycin may also be used for the prophylaxis, and as a component of regimens in the treatment, of Mycobacterium avium complex MAC infections. It is used in some countries for the prophylaxis of endocarditis in atrisk patients unable to take penicillin. It is also used in the management of trachoma and typhoid. For details of all these infections and their treatment, see under Choice of Antibacterial. Azithromycin has been tried in protozoal infections such as babesiosis below , crytosporidiosis, and toxoplasmosis.
It is given orally or by intravenous infusion usually as the dihydrate; doses are expressed in terms of the anhydrous substance. Azithromycin dihydrate mg is equivalent to about mg of anhydrous azithromycin. The capsule formulation should be given at least 1 hour before, or 2 hours after, meals.
The usual oral adult dose of azithromycin is mg as a single dose daily for 3 days. Alternatively, an initial dose of mg may be followed by mg daily for a further 4 days. For uncomplicated genital infections caused by Chlamydia trachomatis and for chancroid, 1 g of azithromycin is given as a single dose. A single dose of 2 g has been given for uncomplicated gonorrhoea.
For the treatment of granuloma inguinale, an initial dose of 1 g followed by mg daily may be given, or 1 g may be given once a week for at least 3 weeks, until all lesions have completely healed. In the USA, a modified-release preparation given as an oral suspension is available.
The product delivers a single dose of 2 g and should also be taken on an empty stomach. It is licensed for the treatment of acute bacterial sinusitis or community-acquired pneumonia in adults.
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For prophylaxis of disseminated MAC infections, azithromycin 1. For treatment or secondary prophylaxis, mg once daily should be given with other antimycobacterials. For mild or moderate typhoid caused by mumdrug-resistant strains, mg once daily may be given for 7 days.
For details of doses in infants and children, see below. Azithromycin dihydrate may also be given initially by intravenous infusion to adults in doses equivalent to mg of azithromycin as a single daily dose in the treatment of community-acquired pneumonia and pelvic inflammatory disease; treatment should be changed to the oral route after at least 2 days in pneumonia and after 1 or 2 days in pelvic inflammatory disease. Thus, choose a good liquid foundation, and you're on your way to a beautiful, made up appearance! In growing animals or human beings, deficiency of thyroxine causes growth to be greatly inhibited because of lack of protein synthesis Online Pharmacy In Australia Buy Dapoxetine 30 Online.
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