Sixteen patients in outside hospitals who served as controls were not provided chloroquine. A nasopharyngeal swab was collected every day to detect the presence of the coronavirus. The treated patients were administered mg hydroxychloroquine sulphate tablets thrice a day for 10 days. The primary endpoint was viral clearance at six days.
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Six patients in the hydroxychloroquine group were also given azithromycin for superadded infection; all six patients were free of the virus after six days. In addition, the results of the study change for the worse if the six patients who had dropped out had been included. There is also no information about the three people who had to be shifted to ICUs. The patient who died on day 3 had tested negative for COVID on day 2, but the French team has not explained the cause or manner of death in their paper.
In effect, an observational study of only 20 patients should be considered a pilot study, nothing more. The findings of this study have to be confirmed by larger, randomised controlled trials for the findings to be borne out. The FDA is likely to be looking into this aspect itself.
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Additionally, the WHO has thus far not endorsed this trial either. Other researchers have begun clinical trials with chloroquine to ascertain its efficacy and safety for treating COVID The University of Minnesota is studying the impact of chloroquine on people exposed to the new coronavirus and the results should be available in a few weeks.
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Until then, chloroquine should not be bought over the counter. It should be administered in hospital settings by qualified critical care doctors. But the contrary has happened in Delhi, and probably in the rest of the country as well. People have rushed to pharmacies to buy all the chloroquine available without stopping to ascertain whether the drug works. It would be terrific if a randomised trial reported that chloroquine is efficacious and safe. It is already a generic drug that costs only a few rupees per dose.
Indian drug companies can manufacture it in very large quantities soon. On the other hand, while media outlets have swarmed over the chloroquine controversy, there has been little or no news about a drug combination that actually significantly cut mortality in confirmed coronavirus patients.
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Can Doctors Give It Anyway? Despite the note of caution from experts, drugs stores across the country—just like in the US— reported that they are running out of stocks for hydroxychloroquine, leaving patients with rheumatoid arthritis, for instance, in a difficult situation.
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The WHO has already launched a global mega trial of four most promising treatments for coronavirus, including the combination of hydroxychloroquine and choloroquine. Click here to join our channel TheWeekmagazine and stay updated with the latest headlines. Home News Health. A volunteer wraps a mask on a child at a slum area in the wake of deadly coronavirus, in Bikaner PTI.
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