Status: Shown broad-spectrum activity in vitro against more than 20 RNA viruses in coronaviruses and viral disease families that include filoviruses, togaviruses, bunyaviruses, arenaviruses, paramyxoviruses, and flaviviruses. Type: Anti-necrosis drug whose glyco-polymer structure consists of hybrid molecules integrating the Hemoglobin molecule and a proprietary polymer chemical structure.
The University will use the adjuvant to test the viral protein it is developing with its molecular clamp technology, CSL said. Type: Humanized IgG4 monoclonal antibody. Status: CytoDyn plans to offer an update during a March 5 conference call with analysts about its planned filing of an IND and its Phase II clinical trial protocol with the FDA, as the company seeks to evaluate the leronlimab as a coronavirus treatment.
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CytoDyn and Longen China Group said February 12 they will begin exploring leronlimab as a potential treatment for coronavirus as well as cancer. Leronlimab has successfully completed nine clinical trials in over people, according to CytoDyn, including meeting its primary endpoints in a pivotal Phase III trial in combination with standard antiretroviral therapies in HIV-infected treatment-experienced patients. Japan has approved Avigan for novel or re-emergent influenza and was previously used to treat Ebola patients in Guinea. Status: GSK agreed to provide Clover with its pandemic adjuvant system for further evaluation of S-Trimer in preclinical studies, the companies said February 24, under a research collaboration whose value was not disclosed.
GSK reasons that Clover could rapidly scale-up and produce large-quantities of a new coronavirus vaccine since it has one of the largest in-house, commercial-scale cGMP biomanufacturing capabilities in China. Types: Humanized monoclonal antibody targeting PD-1 Camrelizumab ; 5-Da polypeptide hormone secreted by the thymus gland thymosin. Another 50 boxes have been provided to the Chinese Center for Disease Control and Prevention for laboratory-based investigations. Janssen said it is also working closely with global partners to screen its library of antiviral molecules to accelerate discovery of potential COVID treatments.
No commercial partner to take the coronavirus vaccine to market has been identified, the companies said.
The primary aim of the Phase I open-label, dose-ranging trial study NCT , which had yet to recruit patients at deadline, is to evaluate the safety and reactogenicity of a 2-dose vaccination schedule of mRNA, given 28 days apart, across 3 dosages in healthy adults. When a virus comes in contact with the nanoviricide, the nanomicelle polymer is designed to fuse with the virus lipid envelope. NanoViricides added that it is working on developing collaborations to advance its COVID program should an effective drug candidate be identified.
Erck said February 26 in a statement. Novavax cited progress in its development saying it has produced and is currently assessing multiple nanoparticle vaccine candidates in animal models prior to identifying an optimal candidate for human testing. Five trials including Arbidol were listed on ClinicalTrials.
Sanofi said the DNA sequence encoding the antigen will be combined into the DNA of the baculovirus expression platform and used for rapidly producing large quantities of the coronavirus antigen, which will be formulated to stimulate the immune system to protect against the virus. In non-clinical studies, the SARS vaccine candidate was immunogenic and afforded partial protection as assessed in animal challenge models, Sanofi said.
TNX is under development as a potential smallpox preventing vaccine for the U. Status: Vaxart said January 31 that it plans to generate vaccine candidates based on the published genome of the COVID SARS-nCoV-2 and evaluate them in preclinical models based on their ability to generate both mucosal and systemic immune responses.
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The first U. Of those confirmed cases, just over half 45, have recovered. Those 35 include treatments that have received the greatest public attention in recent days, being developed by companies that range from pharma giants like GlaxoSmithKline and Sanofi, to small and large biotechs such as Moderna and Gilead Sciences. Gilead has begun clinical trials in China after peer-reviewed journals showed its antiviral candidate, remdesivir, having positive results in a case involving an American patient and Chinese in vitro tests.
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Many of those trials are included in the 60 studies listed in ClinicalTrials. The U. The guideline gives priority to drugs that are already marketed, and whose efficacy has been proven in animal and in vitro studies. Because some of the experimental treatments have yet to be named, or identified, each prospective treatment is listed by its developer, followed by the treatment name or description, the type of treatment including its mechanism, and a brief status update summarizing recent developments.
Where applicable, the status updates include links to recent news reports in GEN , as well as to clinical trials pages maintained by U. In many cases, Chinese authorities, hospitals, and companies are studying potential treatments outside the auspices of their original developers. The trial has been prospectively registered with Chinese authorities. Two other recent coronavirus-related collaborations focus on potential targets. And at least one collaboration announced January 28 focuses on a platform with the promise of future treatments: AbCellera said it and partners will apply its pandemic response platform to develop field-ready medical countermeasures within 60 days of isolation of an unknown viral pathogen.
This list is certain to multiply in coming weeks as global health agencies, governments, and drug developers step up efforts against the SARS-CoV-2 virus. Type: HIV-1 protease inhibitor indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children 14 days old and older. The Health Commission of Henan Province announced January 31 that three confirmed cases of patients diagnosed with new coronavirus infections recovered after taking Kaletra, a combination of ritonavir and lopinavir.
As of that date, nucleic acid testing of more than 20 confirmed cases of patients infected with new coronavirus, admitted to hospitals in Zhejiang Province turned negative after taking Kaletra, according to Ascletis Pharma, which is evaluating a combination therapy of its own candidates ASC09 and ritonavir See below.
The companies are pursuing approval for trials in China, and FDA authorization under regulations allowing the export of investigational drugs for use in a sudden and immediate national emergency. Treatment: Single-dose, intranasal vaccine designed to provide systemic immunity.
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Status: Altimmune said February 28 that it completed the design and synthesis of the vaccine, and was advancing it toward animal testing and manufacturing. Clinical testing of the vaccine could start as early as August. Type: Recombinant human angiotensin-converting enzyme 2 rhACE2 developed for the treatment of acute lung injury, acute respiratory distress syndrome, and pulmonary arterial hypertension.
The randomized, unblinded trial will treat 24 patients for seven days to obtain preliminary data on the impact of rhACE2 on biological, physiologic, and clinical outcomes, as well as safety. Tamiflu is distributed in the U. International Journal for Parasitology. Retrieved 28 January Archived from the original on 13 September J Am Chem Soc. Angewandte Chemie International Edition in German.
European Journal of Biochemistry. Natural Product Reports. London: Laurence King. David C.
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Archived 8 May at the Wayback Machine From p. Este arbol tiene una corteza gruessa, muy solida y dura, que en esto y en el color parece mucho a la corteza del palo que llaman Guayacan: en la superfiecie tiene una pelicula delgada blanquisca, quebrada por toda ella: tiene la corteza mas de un dedo de gruesso, solida, y pesada: la qual gustada tiene notable amargor, como el dela Genciana: tiene en el gusto notable astriction, con alguna aromaticidad, porque al fin del mascar la respira della buen olor. Tienen los Indios esta corteza en mucho, y usan de lla en todo genero de camaras, que sean con sangre, o sin ella.
The Indians hold this bark in high regard, and use it for all sorts of diarrhea, that are with blood [i.
The Spanish [who are] tired of this disease, on the advice of the Indians, have used this bark and have healed many of those with it. They take as much as a small bean, make [it into] powder, take it in red wine or in appropriate water, if they have fever or illness: it must be taken in the morning on an empty stomach, three or four times: otherwise, using the order and regimen that suits those who have diarrhea.
Archived 5 May at the Wayback Machine From p. Tiene dos cortezas, la una gruessa muy solida dura, que assi en la sustancia como en el color es muy semejante al Guayacan: la otra es mas delgada y blaquezina, la qual es amarga con alguna estipticidad: y de mas desto es aromatica. Tienen la en mucho nuestros Indios, porque la usan contra qualesquier camaras, tomando de poluo peso de uno drama o poco mas, desatado en agua azerada, o vino tinto.
It has two barks, one [is] thick, very solid, [and] hard, which in substance as well as in color is much like guayacan [i. Our Indians regard it highly, because they use it against any diarrheas, taking a weight of a dram or a bit more of the powder, mixing it in mineral water, or red wine. Malaria Journal.
Hopes are high for a coronavirus treatment, which could come much quicker than a vaccine
New Scientist. Of the Society of Jesus i. Archived 22 May at the Wayback Machine From p. Hernando de Leon Garavito, llevando gran cantidad de la corteza de la quina, cuyo conocimiento extendieron por el mundo los jesuitas. After almost 20 days of sailing, medicine arrived in the city of Panama, where it was transloaded onto mules. It then traveled the malarial isthmus as far as Portobelo, thence to Cartagena [in Colombia] and Havana. Quinine: malaria and the quest for a cure that changed the world. New York, NY: Perennial. Quinine and Quarantine.
De Jussieu accompanied de la Condamine on the latter's expedition to Peru.
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Annales de Chimie et de Physique in French. New York: Nation Books. Also cites Porter, Roy New York: W. Farrar, Straus and Giroux. The Fall of the Philippines. Washington, D. Archived from the original on 25 May Archived from the original on 22 November Leonard D. Heaton, ed. Archived from the original on 29 January Tactical and Technical Trends Archived from the original on 14 October Archived from the original on 26 July Retrieved 27 April FDA Consumer Magazine.
July—August Archived from the original on 15 January Retrieved 31 July Archived from the original on 28 July Retrieved 22 September Retrieved 9th Jul Antiparasitics — antiprotozoal agents — Chromalveolate antiparasitics P Balantidiasis : tetracycline. Blastocystosis : metronidazole.